Billionaire stock picks Paramount Gold and Silver Corp. (NYSEMKT:PZG), Nanosphere, Inc. (NASDAQ:NSPH) and Orexigen Therapeutics, Inc. (NASDAQ:OREX) have made noteworthy climbs on the market this Wednesday. In the red are Shire PLC (ADR) (NASDAQ:SHPG), Cal Dive International, Inc. (NYSE:DVR) and Liberty Interactive Corp (NASDAQ:QVCA).

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Shire PLC

Paramount Gold and Silver Surges on Discovery

Paramount Gold and Silver Corp. (NYSEMKT:PZG) climbed +13.49% today on the heels of news that it has discovered a new high-grade structure in one of its projects in Mexico. A new second quarter buy for billionaire investor George Soros, PZG has climbed +5.81% over the past five days.

[drizzle]Nanosphere, Inc. (NASDAQ:NSPH) got a +11.03% jump today, putting its five-day gain at +51.3%. The molecular diagnostics company, also a new Soros buy, has declined -65.31% in 2014.

Up +10.4%, Orexigen Therapeutics, Inc. (NASDAQ:OREX) is also having a strong day on the market. Late last week, Zacks reinstated its neutral rating of the stock, which has been in the Farallon Capital portfolio since the first quarter of 2013.

Shire Dives on AbbVie Pullback

Shire PLC (ADR) (NASDAQ:SHPG) plunged -30.32% today after AbbVie announced that it is reconsidering its $55 billion tender offer for the company. The stakes are high on this one for billionaire hedge fund manager John Paulson, who as of Q2 2014 holds 3.37 million SHPG shares. Farallon Capital has a position in the biotech company as well. Despite today’s dip, Shire is up +21.67% YTD.

Cal Dive International, Inc. (NYSE:DVR) dipped -20.95% today, putting its five-day loss at -62.95%. A new Q2 buy for George Soros, DVR is down -84.05% YTD.

The share price of Liberty Interactive Corp (NASDAQ:QVCA) dropped -17.45% today, bringing its YTD loss to -20.65%. At the start of the month, the company announced that it will split QVC from its other e-commerce assets to form two units, and since that time, its price has declined -17.21%. Ray Dalio declared a small 11,000-share position in the company in Q2.

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