The way doctors examine the bladder for tumors or stones is like exploring the contours of a cave with a flashlight. Using cameras attached to long, flexible instruments called endoscopes, they find that it’s sometimes difficult to orient the location of masses within the bladder’s blood vessel-lined walls.

3D Bladder Map
Image source: YouTube Video Screenshot
3D Bladder Map

This could change with a new computer vision technique that creates three-dimensional bladder reconstructions out of the endoscope’s otherwise fleeting images. With this fusion of medicine and engineering, doctors could develop organ maps, better prepare for operations, and detect early cancer recurrences.

“The beauty of this project is that we can take data that doctors are already collecting,” says Audrey Bowden, assistant professor in the electrical engineering department at Stanford University. She is a co-senior author of a recent paper in Biomedical Optics Express that describes the method.

Don’t throw out that data

Bladder cancer has among the highest recurrence rates of any cancer. From 50 percent to 70 percent of tumors return after removal, according to Joseph Liao, an associate professor of urology at the School of Medicine and co-senior author of the paper. Being able to see each patient’s bladder as a three-dimensional model could improve surgical planning and monitor cancer recurrence.

“Sometimes you don’t have a sense—where was I in the bladder?”

“Endoscopy of the bladder, called cystoscopy, is an integral part of cancer management. Anything you can do to improve endoscopy is helpful,” Liao says. “Surgeons are always looking for better ways to see cancer in order to remove it more effectively.”

One of the technique’s advantages is that doctors don’t have to buy new hardware or modify their techniques significantly. Through the use of advanced computer vision algorithms, the team reconstructed the shape and internal appearance of a bladder using the video footage from a routine cystoscopy, which would ordinarily have been discarded or not recorded in the first place.

“In endoscopy, we generate a lot of data, but currently they’re just tossed away,” says Liao.

Other hollow organs

Although the team developed the technique for the bladder, it could be applied to other hollow organs where doctors routinely perform endoscopy, including the stomach or colon. “We were the first group to achieve complete 3D bladder models using standard clinical equipment, which makes this research ripe for rapid translation to clinical practice,” says Kristen Lurie, lead author on the paper, a recent PhD graduate and postdoctoral fellow at Stanford, and a current software engineer at Google.

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According to Liao, these three-dimensional images could help doctors prepare for surgery. Lesions, tumors, and scars in the bladder are hard to find, both initially and during surgery.

“Sometimes you don’t have a sense—where was I in the bladder?” Liao says. Seeing a three-dimensional rendering of an organ before operating, like having a map before embarking on a trip, could make the procedure easier for doctors. Other potential applications include using the 3D reconstruction as a visual medical record.

Testing on a ’tissue phantom’

To test the accuracy of their bladder reconstruction, the team first created a model based on endoscopy images taken in a 3D-printed bladder, known as a tissue phantom. Because the details of the tissue phantom are known, the researchers could directly compare their rendering to the real thing. According to Bowden, tissue phantoms provide a standard for biological modeling analysis. The team found that its three-dimensional rendering matched the tissue phantom with few errors.

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This technique is the first of its kind and still has room for improvement, the researchers said. Primarily, the three-dimensional models tend to flatten out bumps on the bladder wall, including tumors. With the model alone, this may make tumors harder to spot. The team is now working to advance the realism, in shape and detail, of the models.

Future directions, according to the researchers, include using the algorithm for disease and cancer monitoring within the bladder over time to detect subtle changes, as well as combining it with other imaging technologies.

“The technology has immense potential, not to mention the fun factor to be able to navigate around a virtual organ,” Liao says.

An NSFGRFP fellowship and the Max Planck Center for Visual Computing and Communication supported the work.

Source: Jackie Flynn for Stanford University

Original Study DOI: 10.1364/BOE.8.002106

Article by Amy Adams-Stanford